GWAS summary data tables

Feenstra B et al. Common variants associated with general and MMR vaccine-related febrile seizures. Nature Genetics 2014; 46: 1274-1282; doi:10.1038/ng.3129

We are releasing the summary data from our genome-wide meta-analyses of febrile seizures published in Feenstra et al. 2014 (https://www.nature.com/articles/ng.3129).

The files include results for approximately 8.1 million (MAF>1%) directly genotyped or imputed variants to the integrated Phase I release of the 1000 Genomes Project reference panel.

Four genome-wide association meta-analyses were conducted (see paper for full details):

  1. Measles, mumps and rubella (MMR) vaccine-related febrile seizures versus controls.
  2. MMR vaccine-related febrile seizures versus MMR-unrelated febrile seizures.
  3. MMR-unrelated febrile seizures versus controls.
  4. Febrile seizures overall versus controls.

Logistic regression was used to test for differences in allele dosage between cases and controls under an additive genetic model. Summary files provide information on chromosome, genomic position (NCBI build 37), rsID, effect allele, other allele, effect estimate (beta) for the effect allele, standard error, and P value, at approximately 8.1 million variants passing quality control.

Acknowledging the data

When using data from the downloadable meta-analyses results please acknowledge the source of the data as follows:

Data on febrile seizures has been contributed by Statens Serum Institut researchers and has been downloaded from https://www.danishnationalbiobank.com/GWAS.
 In addition to the above acknowledgement, please cite the paper below:

Feenstra B et al. Common variants associated with general and MMR vaccine-related febrile seizures. Nature Genetics 2014; 46: 1274-1282; doi:10.1038/ng.3129.

Downloading the data

Dataset details

We have four sets of summary files. The data can be downloaded here in gzipped text file format.

  1. Measles, mumps and rubella (MMR) vaccine-related febrile seizures (n=929) versus controls (n=4118)
  2. MMR vaccine-related febrile seizures (n=929) versus MMR-unrelated febrile seizures (n=1070)
  3. MMR-unrelated febrile seizures (n=1070) versus controls (n=4118)
  4. Febrile seizures overall (n=1999) versus controls (n=4118)

Disclaimer

These data are provided "as is" and without warranty, for scientific and educational use only. The authors assume no responsibility for errors or omissions. If you download these data, you acknowledge that these data will be used only for non-commercial research purposes; that the investigator is in compliance with all laws or regulations and institutional policies regarding human subjects and genetics research; and that secondary distribution of the data is prohibited. The authors shall not be held liable for any use or misuse of the data.