GWAS summary statistics (2025)

The files include results for approximately 9.6 million (MAF>1%) directly genotyped or imputed variants.

Dataset details

The GWAS summary statistics files contains results from:

• Quantitative trait analyses of plasma sodium concentrations (n=188,461).
• Quantitative trait analyses of change in sodium concentration with thiazide exposure (n=14,327).
• Case–control analyses of thiazide-induced hyponatremia (strict definition 392 cases versus 16,336 thiazide-using, normonatremic controls).
• Case–control analyses of thiazide-induced hyponatremia (broader definition 829 cases versus 16,336 thiazide-using, normonatremic controls).

The files provide information on chromosome, genomic position (NCBI build 38), marker name, rsID, effect allele, other allele, beta for the effect allele, standard error, and P value, at approximately 9.6 million variants passing quality control.

Acknowledging the data

When using data from the downloadable meta-analyses results please acknowledge the source of the data as follows:

Data on sodium related traits have been contributed by Statens Serum Institut researchers and have been downloaded from http://www.danishnationalbiobank.com/GWAS.html

In addition to the above acknowledgement, please cite the paper below:

Andersson NW, Wu X, Geller F, Wohlfahrt J, Melbye M, Hviid A, Schwinn M, Mikkelsen C, Dowsett J, Bruun MT, Aagaard B, Ullum H, Erikstrup C, Gudbjartsson DF, Stefánsson K, DBDS Genomic Consortium, Ghouse J, Pedersen OB, Sørensen E, Ostrowski SR, Bundgaard H, Lund M, Feenstra B. Genome-wide association study of plasma sodium concentrations with and without exposure to thiazide diuretics. Journal of the American Society of Nephrology 2025. (https://doi.org/10.1681/ASN.0000000622).

Downloading the data

1. GWAS of plasma sodium concentrations
Link: https://biobanks.dk/GWAS/sodium_FINAL_b38.txt.gz

2. GWAS of change in sodium concentration with thiazide exposure
Link: https://biobanks.dk/GWAS/tih_quantitative_ln_diff_FINAL_b38.txt.gz

3. GWAS of thiazide-induced hyponatremia (strict definition)
Link: https://biobanks.dk/GWAS/tih_case_control_strict_FINAL_b38.txt.gz

4. GWAS of thiazide-induced hyponatremia (broader definition)
Link: https://biobanks.dk/GWAS/tih_case_control_broader_FINAL_b38.txt.gz

Disclaimer

These data are provided "as is" and without warranty, for scientific and educational use only. The authors assume no responsibility for errors or omissions. If you download these data, you acknowledge that these data will be used only for non-commercial research purposes; that the investigator is in compliance with all laws or regulations and institutional policies regarding human subjects and genetics research; and that secondary distribution of the data is prohibited. The authors shall not be held liable for any use or misuse of the data.